Crossreaction of antilymphocyte globulin with human granulocyte colony-forming cells.

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Crossreaction of antilymphocyte globulin with human granulocyte colony-forming cells.

Clinical preparations of horse antilymphocyteglobulin (ALG) were found to inhibit human bone marrow granulocyte colony growth. This effect was enhanced by complement and was dose dependent, being almost complete at ALG concentrations of 100 microgram/ml. Inhibition was a property of ALG but not of normal horse globulin. However, short incubation of ALG with bone marrow cells occasionally stimul...

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Antilymphocyte Globulin, Cyclosporin, and Granulocyte Colony-Stimulating Factor in Patients With Acquired Severe Aplastic Anemia (SAA):

Patients with severe aplastic anemia (SAA) and a neutrophil (PMN) count of less than 0.5 x 109/L are exposed to a high risk of early mortality when treated with antilymphocyte globulin (ALG) and steroids, with the major problem being infectious complications. The addition of human recombinant granulocyte colony-stimulating factor (rhG-CSF) to ALG may reduce early mortality by improving neutroph...

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Mesenchymal Stem Cells with Granulocyte Colony-Stimulating Factor Reduce Stress Oxidative Factors in Parkinson\'s Disease

Background: Recent studies have shown that bone marrow mesenchymal stem cells (BMSCs) have a putative ability to promote neurogenesis and produce behavioral and functional improvement. Our previous study demonstrated that co-treatment of granulocyte colony-stimulating factor (G-CSF) and BMSCs have beneficial effects on Parkinson's models. The main purpose of this research was to investigate the...

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Reduction of antibody plaque-forming cells by allogeneic antilymphocyte serum.

Allogeneic mouse antilymphocyte serum effectively reduced the number of antibody plaque-forming cells after the natural antilytic property had been eliminated by dilution.

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Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells.

The effects of direct activators of protein kinase C (PKC) (the phorbol ester tetradecanoyl phorbol myristic acid [TPA] or bryostatin) on the ability of a highly enriched population of granulocyte-macrophage colony-forming cells (GM-CFC) to proliferate and develop in soft agar was assessed. In the absence of colony stimulating factors, the PKC activators did not stimulate colony formation. Howe...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1978

ISSN: 0021-9746

DOI: 10.1136/jcp.31.2.129